Peak hour effects were uniformly, but moderately larger than trough effects, with the trough to peak ratio for systolic and diastolic responses 50-95 and 60-90 respectively. Contraction stress testing CST non-stress test NST or biophysical profiling BPP may be appropriate, depending upon the week of pregnancy. Percent, respectively, of patients with essential hypertension treated with HYZAAR alone. There was no evidence of teratogenicity in rats or rabbits treated with maximum losartan potassium dose of 10 mg kg day in combination with. Pharmacokinetics General Losartan Potassium Losartan is an orally active agent that undergoes substantial first-pass metabolism by cytochrome P450 enzymes. These data suggest that the conversion of losartan to its active metabolite is mediated consultare il medico hyzaar primarily by P450 2C9 and not P450 3A4. Another study investigated the dose-response relationship of various doses of hydrochlorothiazide.