Laura H replied: "I have been taking metformin for a good long time, and I know your worries over the high numbers. Like with any other medication, it does take time for your body to adjust to any new medication. You have to watch your carbohydrate intake. You are to take metformin with food and you can take it up to 30minutes to an hour before you eat or after you eat. The important thing to do is to take it. Do not brake it inhalf with the knife. You need to take it in its original form. You should be eating between 30-45 grams of carbohydrates per meal. Your fasting level should fall within the range of 90-130mg/dl 2-hours after you eat it should be 180 or lower and before you eat it should be at least 130 or lower. You can mange diabetes with metformin. Eating lower fattened foods is better for diabetics as well. When your sugar was 297, how long had it been since you took the medication in comparison to how soon you ate. If this within an hour of medication and food, then this would not be that much to worry over. If it was 2-hours after, then yea it was a little high, but you could have eaten too many carbs, or you might not have eaten enough. You have to eat and make notes about what works for you and what doesn;t You should not go longer than 5 hours at any time without eating something. For instance my blood sugars, I try to eat within every 4 to 5 hours of when I ate my last meal. For example this morning breakfast was at 9.11am and I was eating lunch at 1.09 and then supper will be between the 5 and 6pm hour. you can lose weight on metformin and another thing, if the 500mg is not lowering your blood sugar as it shoulf be your doctor may raise your dosage to 850 or 1000mg daily. Hope this helps and keep taking the medication, it does work. It just takes time and patience and endurance to live with this disease and having to cope with it. Good Luck. Laura"