cindy j replied: "I am glad you asked this question. I am in the same boat. I am only 1 wk. pregnant and my doc. has prescribed me prometrium 100mg. once daily. I was on progesterone vaginal gel prochieve 8% before but, it gave me severe vaginal irritation. I would be watching the replies you get. How many times has your doctor prescribed it? Are you pregnant. Thanks for posting this."

ljb replied: "To answer your question about why prometrium makes you feel pregnant: it's synthetic progesterone, and it's the elevated levels of progesterone that's responsible for a lot of pregnancy symtpoms (and that is also responsible for a lot of pre-menstrual symptoms). That's also why, incidentally, when people ask "what are the early signs of pregnancy" a very safe answer is "pretty much any of the signs that tell you your period is coming" -- same hormone at work. Extreme fatigue is *very* common, and if you're only taking prometrium 1x/day you should take it at night, rather than in the morning, for that very reason. As for the bloodwork, the basic "infertility workup" consists of bloodwork on "CD21" (it should be done at 7 day post-ovulation -- so if you ovulate on, say, day 20 of your cycle the bloodwork shouldn't be done until day 27), and bloodwork done on CD3. The CD3 testing checks your FSH levels (which indicates ovarian reserves) and estradial. I believe it's also the CD3 testing that checks prolactin and some other things (it's been a while, I don't remember exactly what was checked with what test). Another standard test is the hysterosalpingogram (referring to as the "hsg" -- and I probably botched the spelling anyway) -- this is a test in which dye is run through the woman's fallopian tubes to check for any blockage. It's not a long procedure and generally not anymore uncomfortable that menstrual cramping can be, although if there is a blockage it can be more uncomfortable. There is also some evidence that fertility increases after an hcg is performed because the procedure essentially "cleans out" the tubes. There's plenty of good information on the Web about basic fertility workups -- one site with some good information can be found at. I also recommend the message boards at -- they're great for women trying to conceive, generally, and the women will have lots of helpful information and answers about fertility testing, etc. There's probably also great advice from the women on the message boards at (don't let the URL scare you off). I've taken prometrium and remember the side effects, for sure. But prometrium is not a fertility drug in itself -- for women with low progesterone levels it's hoped the prometrium will help sustain a pregnancy, if pregnancy is achieved (I don't know why your doctor has you on it though, and my experience with it may not be relevant to yours). I did get pregnant while on prometrium, but my issue was recurrent pregnancy loss -- and the prometrium did not help in that regard, sad to say. I hope all goes well for you...and that you get pregnant before the testing is even done! Best of luck."

phaig93 replied: "prometrium is a form of progesterone: and progesterone helps us (women) like this: outtake: prepare the uterus for implantation Good luck!"

Ally_Cali replied: "Hi, I'm going on 3 months late and my doc presecribed me Prometrium in the same dosage as you. Originally she said I would get my period on the 4th day after the 10 day cycle but when I didn't have my period on the 5th day she said it could take up to 2 weeks. I'm on day 9 now and still waiting......hope this helps!"

lisaloxx replied: "Not sure about the girl thing. It's more about the sperm than the woman. But prometrium will bring on a period if you did not conceive this time around. What prometrium does is it increased your progesterone during the luteal phase. What this is , is when the uterine lining gets all "fluffy" and ready to sustain a pregnancy. If the progesterone is low, then there isn't enought uterine lining to keep the pregnancy and implant. Prometrium will help with that. But if an egg did not fertilize then a normal period will occur. Periods are when the unterine lining sheds and the body expells the lining which ends up making you bleed. Thus, your period. It sound to me that you didn't get pregnant this time and so the unterine lining that the prometrium helped create is starting to shed and you are having a period. Good luck next time."

winona e replied: "Why don't you ask your doctor??? He/she is the best person to consult."

grk31589 replied: "from what i read the drug is a type of hormone replacment therapy... go here: hopefully that will help you some!"

justagirl replied: "Ive taken it. Prometrium is progesterone in a pill. I had to take it when I got pregnant because my body wasnt producing enough of it. progesterone is a hormone that your body needs for a pregnancy to progress. I copied this for you and also enclosed a link. I hope this helps: What does progesterone do? Helps to regulate the menstrual cycle. Prepares the lining of the uterus for implantation. Keeps the lining of the uterus thick which is necessary for a successful pregnancy. Produces a rise in temperature after ovulation, which remains until menstruation occurs. Creates a nutrient rich environment for the baby by increasing glycogen and arterial blood to the lining of the uterus. Keeps the uterus from having contractions. Causes the cervix to thicken and create a mucous plug which prevents bacteria from entering the uterus."