Arcion is currently conducting Phase 2b clinical trial of ARC-4558 for the treatment of painful diabetic neuropathy PDN. Sudden cessation of clonidine treatment has, in some cases, resulted in symptoms such as nervousness, agitation, headache, and tremor accompanied or followed by rapid rise in blood pressure and elevated catecholamine concentrations in the plasma. Analysis of skin reaction data showed that the risk of having to discontinue CATAPRES-TTS treatment because of contact dermatitis was greatest between treatment weeks and 26, although sensitivity may develop either earlier or later in treatment. Even though psychostimulants remain the treatment of choice, its cost and availability in developing countries limits the usage of the drug. Clonidine side effects Get emergency medical help if you have any of these signs of an allergic reaction: difficulty swelling of your face, lips, tongue, or throat. This action results in reduced sympathetic outflow from the central nervous system and in decreases in peripheral clonidine yossa resistance, renal vascular resistance, heart rate, and blood pressure.