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The median baseline CD4 cell count had been 162, but was around 463 at the time of switch. Calendar year of commencing HAART and NRTI backbones were significant predictors of virological success and treatment failure, explaining differences in data to the 2NN study. What these studies demonstrate is that the heightened risk associated with high CD4 is not present if that CD4 count has risen on ART from low baseline CD4. The price of boosted protease inhibitor-based second-line HIV treatment will also fall significantly to an annual cost per patient of 590. Joao nevirapine apotheke et al reported very low rates of toxic-ity in 192 subjects, with only one case of SJS, and one grade IV liver toxicity but the mean duration of nevirapine exposure in this retrospective cohort was only 19.

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