Total of 203 patients 74 females and 129 males who were receiving inhaled corticosteroids at study entry were randomized to either ADVAIR DISKUS 100 50 or fluticasone propionate inhalation powder 100 mcg twice daily. Other drugs besides salmeterol which may affect the heart rhythm QTc prolongation in the EKG include amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, and sparfloxacin, among others. Salmeterol produced no detectable or reproducible increases in microbial and mammalian gene mutation in vitro. Due to the potential increased risk of cardiovascular adverse events, the concomitant use of salmeterol with salmeterol cod strong CYP3A4 inhibitors. An 18-month study in mice and lifetime study in hamsters showed no evidence of tumorigenicity. 16 Bronchospasm, exercise-induced prophylaxis Oral inhalation, or inhalations 10 or 20 mcg at least fifteen minutes before exertion. HPA Axis Effects: Short-cosyntropin stimulation testing was performed both at Day and Endpoint in 101 patients with COPD receiving twice-daily ADVAIR DISKUS 250 50, fluticasone propionate powder 250 mcg, salmeterol powder 50 mcg, or placebo.