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Before taking doxepin, tell your doctor if you are allergic to any drugs, or if you have: bipolar disorder manic-depression or diabetes doxepin may raise or lower blood sugar. In the Complete Response Letter, the FDA raised number of issues relating to the interpretation of the efficacy data contained in the Silenor NDA and indicated that the FDA was open to discussion of these concerns. At higher than usual clinical doses, norepinephrine response was potentiated in animals. It should be noted that Sinequan is not approved for use in treating bipolar depression. Psychotic depressive disorders with associated anxiety including involutional depression and manic-depressive disorders. For example, statements regarding the review process and the potential approval doxepin uberdosierung of the NDA for Silenor are forward looking statements.

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