If you notice any of the following highly unlikely but very serious side effects, stop taking itraconazole and tell your doctor immediately: yellowing eyes skin, dark urine, persistent nausea vomiting, stomach abdominal pain. Itraconazole solution is usually taken on an empty was bedeutet itraconazole wie stomach once or twice day for to weeks or longer. If heart failure signs or symptoms occur during therapy, discontinue drug. HMG CoA-Reductase Inhibitors Human pharmacokinetic data suggest that SPORANOX inhibits the metabolism of atorvastatin, cerivastatin, lovastatin, and simvastatin, which may increase the risk of skeletal muscle toxicity, including rhabdomyolysis.