The median difference in time to healing between placebo and the Famvir-treated groups was. Penciclovir triphosphate has an intracellular half-life of 10 hours in HSV-1-, 20 hours in HSV-2- and hours in VZV-infected cells grown in however, the clinical significance is unknown. Resistance Penciclovir-resistant mutants of HSV and VZV can result from mutations in the viral thymidine kinase TK and DNA polymerase genes. The degree of toxicity to male famvir apotheek reproduction was related to dose and duration of exposure. Erythema multiforme jaundice, thrombocytopenia, hallucinations, dizziness, somnolence and confusion including delirium, disorientation, confusional state, occurring predominantly in the elderly.