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Please inform your doctor or pharmacist if you have previously experienced such an allergy. What other drugs will affect loperamide? Before taking loperamide, tell your doctor if you are also taking saquinavir Invirase. If clinical improvement is not observed after treatment with loperamide overdosis 16 mg per day for at least 10 days, symptoms are unlikely to be controlled by further administration. In studies designed to examine the potential for side effects, intentional ingestion of up to 60 mg of loperamide hydrochloride in single dose to healthy subjects resulted in no significant adverse effects. The P-glycoprotein is involved in keeping certain drugs out of certain body tissues the central nervous system in particularly. Com The documents contained in this web site are presented for information purposes only.